Effects of FK506 on anti-glomerular basement membrane nephritis in rats
- VernacularTitle:普乐可复防治大鼠抗肾小球基底膜肾炎的实验研究
- Author:
Renxian TANG
;
Yingwei WANG
;
Rui HUANG
;
Fengguang GAO
;
Xiaome LIU
- Publication Type:Journal Article
- Keywords:
FK506;
Anti-GBM nephritis;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of FK506 on anti-glomerular basement membrane(GBM) nephritis in rats. METHODS: Anti-GBM nephritis model was elaborated by rabbit anti-rat GBM antibody injection in SD rats in this study. The rats were divided into three groups: FK506 treated group(0 5 mg?kg -1 ?d -1 , sc), untreated nephritis control group and normal control group. FK506 was administered daily six hours after injection of anti-GBM IgG. All the rats were observed urinary protein at the 4th day, the 14th day and the 21st day. At the same time, the kidney specimens were collected, and T cell transforming function was also monitored. RESULTS: Rats injected with rabbit anti-GBM Ab developed heavy proteinuria by 4 days, and serum creatinine and serum urea appeared which kept on the rising. Glmerular hypercellularity, crescents, and protein casts were observed in nephritic rats. By electron microscopy, the thickening of GBM and loss of foot processes were seen. T cell transforming function was higher than normal. But, all pathological changes obviously turned for the better in FK506 treated group. CONCLUSION: FK506 could inhibit the progression of rat anti-GBM nephritis.
