APE/Ref-1 protein and ischemia/reperfusion injury of neurons in the brain
- VernacularTitle:APE/Ref-1蛋白与脑缺血/再灌注神经元损伤
- Author:
Xiaosong WANG
;
Zhiwen LI
- Publication Type:Journal Article
- Keywords:
APE/Ref-1 protein;
Brain ischemia;
Neurons;
DNA damage;
DNA repair
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia and the aftermath of reperfusion form a hypoxic/hyperoxic sequence of events that can trigger DNA damage in neurons of central nervous system. Neuronal apoptosis will happen without immediate DNA repair. APE/Ref-1 is a multifunctional protein involoved in DNA base excision repair pathway and in redox reguiation of DNA-binding activity of AP-1 family members, which may play an important role in protection of postischemic neuronal damage.
