Interaction of reactive oxygen species in atherogenetic properties of advanced glycation end products in diabetes
- VernacularTitle:活性氧与糖基化终产物致动脉粥样硬化作用的关系
- Author:
Jie FENG
;
Naifeng LIU
- Publication Type:Journal Article
- Keywords:
Reactive oxygen species;
Arteriosclerosis;
Diabetes mellitus
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
There is overwhelming evidence for an involvement of reactive oxygen species(ROS) in the pathogenesis of atherosclerosis(AS) in diabetes mellitus(DM). For many years, knowledge on the contribution to diabetic complications and vascular disease induced by advanced glycation end-products(AGEs)has been rising. During the development of atherosclerosis, AGEs and ROS might have interaction. In this article, we provided four angles of view to discuss the role of ROS in the pathogenesis of atherosclerosis: the chemistry of ROS, the effect of vascular targets of ROS on activity of AGEs, the role of ROS in the pathogenesis of atherogenesis by AGEs, the same effect of ROS and AGEs-transcriptional regulation. [
