Effects of Glutamine on Hypermetabolism Reaction and Hormone Secretion After Severe Burn Injury
- VernacularTitle:谷氨酰胺对大鼠烧伤后代谢率变化及相关激素分泌的影响
- Author:
Xi PENG
;
Zhongyi YOU
;
Pei WANG
- Publication Type:Journal Article
- Keywords:
Glutamine;
Hypermetabolism;
Hormone;
Rat;
Burn
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of glutamine on hypermetabolism reaction and hormone secretion after severe burn injury. Methods Eighty-eight Wistar rats were inflicted with 30% total body surface area full thickness burns and randomly divided into two groups: namely burned control (B) and glutamine treatment(GLN) group. There was isonitrogenous and isocaloric intake in both groups, and rats of GLN and B groups were given glutamine and glycine at 1 0g/kg d, respectively. The following indices including the resting energy expenditure (REE), the levels of plasma cortisol, insulin and glucagon were determined. Results After burn injury, the REE, plasma cortisol,insulin and glucagons levels were significant increased in both groups. Compared with B group, the level of REE decreased and the ratio of insulin/glucagons increased in GLN group. Correlation analyses showed that REE had a negative correlation with insulin/glucagons ratio (r=-0 78,P