Effects of Recombinant Human Growth Hormone in the Treatment of Disease with Growth Hormone Deficiency
- VernacularTitle:重组人生长激素治疗垂体性侏儒症对身高骨骼和器官发育的影响
- Author:
Jing JIANG
;
Wei WANG
;
Wenxin SUN
- Publication Type:Journal Article
- Keywords:
rhGH;
GHD;
BA;
Pulmonary function
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of both domestically manufactured and imported recombinant human growth hormone (rhGH) in the treatment of growth hormone deficiency(GHD) disease. Methods 67 patients with GHD were given domestically manufactured rhGH ,while imported rhGH were given to another 19 boys with GHD. The dose of rhGH in both groups was 0 1IU?Kg -1 ?d -1 . 19 boys with GHD received imported rhGH for 24 months in combination with administration of chorionic gonadotropin or Testoviron Depot in second year. Vital Capacity (VC) and Maximal Ventilation Volume(MVV) before and 6,12 months after rhGH treatment were measured in 10 cases. Results The increase in linear growth was significant in both groups. In 19 boys with GHD, HA was direct proportion to BA before and 6,12,18,24 months after treatment. In 10 boys with GHD, 12 months after rhGH treatment, VC and MVV significantly increased as compared with pre-treatment (P
