Identification of Hereditary Symmetrical Dyschromatosis Susceptibility Locus by Genome-wide Scan
- VernacularTitle:全基因组扫描定位遗传性对称性色素异常症易感区域
- Author:
Min GAO
;
Xuejun ZHANG
;
Ming LI
;
Chengrang LI
;
Yong CUI
;
Pingping HE
;
Ming LI
;
Wentao YUAN
;
Shijie XU
;
Sen YANG
;
Wei HUANG
- Publication Type:Journal Article
- Keywords:
Chromosome mapping;
Linkage(Genetics);
Haplotypes;
Dyschromatosis symmetrica hereditaria
- From:
Chinese Journal of Dermatology
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify a locus for hereditary symmetrical dyschromatosis(HSD).Methods A genome-wide scan was performed with402microsatellite markers in two large Chinese HSD families to map the chromosome location of the susceptible gene.The LINKAGE software(Version5.10)and CYRILLIC soft-ware(Version2.01)were used for linkage and haplotype analysis.Results A locus was identified at chro-mosome1q11-1q21with a cumulative maximum two-point LOD score of8.85at microsatellite marker D1S2343(?=0.00).Haplotype analysis indicated that the candidate gene was located within11.6cM region between markers D1S2696and D1S2635.This was the first locus identified for HSD.This study provided a map location for isolation of the candidate genes causing HSD.Conclusion Chromosome1q11-1q21contains the candidate gene susceptible for dyschromatosis symmetrica hereditaria.
