Enhanced Expression of Platelet-derived Growth Factor Receptor Proteins in Keloids
- VernacularTitle:血小板衍化生长因子受体蛋白在瘢痕疙瘩中的表达
- Author:
Xiaodong CHEN
;
Qiang WANG
;
Guocheng ZHANG
;
Shunzhang YE
- Publication Type:Journal Article
- Keywords:
Keloid;
Receptors,platelet-derived growth factor;
Fibroblasts
- From:
Chinese Journal of Dermatology
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and localization of platelet-derived growth factor receptor-?and-?(PDGFR-?and-?)in keloid tissues and keloid-derived fibroblasts and to explore the role of PDGFR in the pathogenesis of keloid.Methods The distribution of PDGFR was determined by im-munohistochemistry technique in15keloid lesions and10normal skin tissues.The expression of PDGFR protein in vitro was identified by Western blotting analysis.Results Strong staining of PDGFR-?was locat-ed in keloid tissue.However,the expression of PDGFR-?in keloid tissue seemed to be related to the status of clinical proliferation.Strong expression of PDGFR-?was observed in the lesions with a congestive and invasive margin,whereas mild expression of PDDFR-?was found in lesions with a stable margin.Expression of PDGFR-?protein was more abundant than that of PDGFR-?protein in fibroblasts in vitro.Conclusion The elevated levels of both types of PDGFR might facilitate their responses to PDGF in keloid fibroblasts,which seems to play an important role in the formation of keloid.
