Evaluation of Cumulative Skin-irritation of Six Commercinlly Available Topical Retinoic Acid Preparations
- VernacularTitle:市售六种维A酸外用制剂对皮肤累积刺激性的评估
- Author:
Zhigang BI
;
Meihua ZHANG
;
Zhonglan SU
;
Guohong LIU
;
Xiaojun ZHANG
;
Donghua LOU
;
Bian ZHAO
- Publication Type:Journal Article
- Keywords:
Retinoids;
Skin irritancy tests;
Administration,cutaneous
- From:
Chinese Journal of Dermatology
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the cumulative irritative effect of topical retinoic acid preparations on normal skin.Methods A randomlized,doubled blind,placebo-controlled clinical trial was carried out with7groups for6tested preparations.All subjects were patch tested with each preparation for24hours on Monday to Thursday,and for72hours on Friday.The patch tests were performed for3consecutive weeks.Results The minimal cumulative irritative effects were found in Group G treated with0.1%adapalene gel,with a cumulative irritative index of0.09?0.11in20days.The cumulative irritative index was significantly lower in Group G than that in Group B treated with0.1%retinoic acid(Diweishuang誖)(0.59?0.24),or in0.025%retinoic acid(Diweishuang誖)(0.41?0.22),or in0.05%retinoic acid(VITAMIN誖Cream)(0.25?0.22).Conclusion Adapalene,the third generation of retinoic acid,is characterized by lower irritative ef-fects in comparison to the first generation of topical retinoic acid agents.
