Expression of NOS in the rat colorectal carcinoma cells
- VernacularTitle:一氧化氮合酶在大鼠大肠癌细胞中的表达及意义
- Author:
Jianghua ZHAN
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Nitric oxide synthase
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of nitric oxide synthase (NOS) during the development of rat colorectal carcinoma. Methods Rat colon carcinoma was induced by injection of 1,2- dimethylhydrazine (1,2-DMH).The expression of eNOS, nNOS and iNOS in normal colon mucosa and colorectal carcinoma was observed by immunohistochemistry. ResultseNOS and nNOS were expressed in normal mucosa. Neither eNOS nor nNOS alterations were observed in carcinoma tissues,iNOS expression was very strong in carcinoma samples(87%)and only 10% in normal colon mucosa. ConclusionOur results show that iNOS may play an important role in the 1,2-DMH induced colon tumorigenesis.
