A study on the mechanism of altered gastrointestinal motility in portal hypertensive rats
- VernacularTitle:门静脉高压症大鼠胃肠动力变化及其机制的研究
- Author:
Yongwei SUN
;
Meng LUO
;
Hui CAO
;
Zhiyong WU
;
Zhiping CHEN
- Publication Type:Journal Article
- Keywords:
Hypertension, portal;
Gastrointestinal motility;
Myoelectric complex, migrating;
Gastrointestinal hormones
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the mechanism of altered gastrointestinal motility in portal hypertensive rats. Methods Thirty-two male Sprague-Dawley rats were divided into four groups:sham- operation control (SO, n=8), prehepatic portal hypertension by partial stenosis of the portal vein (PHPH, n=8 ), intrahepatic portal hypertension induced by injection of CCl 4 (IHPH, n=8), and intrahepatic portal hypertension with portacaval shunt (IHPH-PCS, n=8). Gastrointestinal myoelectrical activity and motility were monitored. Gastrointestinal hormones were measured with radioimmunoassay.Results Compared with SO rats, gastrointestinal motor index(MI) were reduced and abnormal myoelectrical activity were recorded (P
