Protection of Ulinastatin on gut barrier in septic rats
- VernacularTitle:胰蛋白酶抑制剂对脓毒症大鼠肠黏膜屏障的保护作用
- Author:
Lianyue YANG
;
Zhili YANG
;
Wei WANG
;
Jixiang PENG
;
Gengwen HUANG
- Publication Type:Journal Article
- Keywords:
Trypsin inhibitors;
Sepsis;
Permeability, bowel;
Gut barrier
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective role of Ulinastatin UTI on gut barrier of septic rats. Methods Twenty-two SD rats were divided into three groups: sham laparatomy(S), cecal ligation and punture(CLP), and CLP plus UTI. Septic rat model was estabilished through CLP method. Fluorescence spectrometry was used to measure FITC-dextran concentration from bowel lumen to portal vein. Ultrastructure of intestinal mucosa was observed under transmission eletron microscope (TEM). Results Twenty-one hrs after CLP septic symptoms in CLP plus UTI group were milder than those in CLP group. Portal concentration of FITC-dextran in CLP group was higher than that of S group[S (1.22?0.21) ?g/ml vs. CLP (2.51?0.56) ?g/ml, P
