Study of Reversing Effect of Nitric Oxide Precursor on Collagen Accumulation in Pulmonary Artery
- VernacularTitle:一氧化氮前体物逆转肺动脉胶原堆积的研究
- Author:
Bing WEI
;
Junbao DU
- Publication Type:Journal Article
- Keywords:
nitric oxide;
L-arginine;
collagen
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the therapeutic effect of L-arginine on collagen metabolism of pulmonary artery in rats with high pulmonary blood flow METHODS:The rat model of pulmonary hypertension was established with an abdominal aorta and inferior vena cava shunting L-arginine was intragastrically given to the rats with shunt in L-arginine group(1g/(kg?d)) for 11 weeks After 11 weeks of experiment,the expressions of collagen Ⅰ and collagen Ⅲ in pulmonary artery were detected by immunohistochemical assay RESULTS:The expressions of collagen Ⅰ and collagen Ⅲ in shunt group elevated obviously compared with those in control group(P
