The Percutaneous Permeability of Methoxypsoralen Liposomal Gel
- VernacularTitle:8-甲氧补骨脂素脂质体凝胶的皮肤渗透性研究
- Author:
Hongxia WU
;
Wen HE
;
Hongsheng CAI
;
Shunde LUO
;
Xianzhou ZHANG
- Publication Type:Journal Article
- Keywords:
methoxypsoralen;
liposomal gel;
permeability
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the percutaneous permeability of methoxypsoralen liposomal gel METHODS:The preparations were applied on the rat skin in vitro and in vivo with common gel and Mingbailing tincture as control,and the drug concentrations in the receiver,skin,blood and other organs were determined by RP-HPLC RESULTS:In vitro experiment,liposomal gel showed the lowest percutaneous permeation rate and the highest retention in skin In vivo studies illuminated that the skin depositions of drug encapsulated in liposome was(4 37?0 91) and (3 36?0 58) times those of the common gel and tincture respectively CONCLUSION:Methoxypsoralen liposomal gel showed an evident targeting effect on skin
