Preparation of Levofloxacin Eyedrops
- VernacularTitle:左旋氧氟沙星滴眼剂的研制
- Author:
Shengchuan GAO
;
Tao GUO
;
Ye AN
- Publication Type:Journal Article
- Keywords:
Levofloxacin;
stability;
sustained-release;
eyedrops
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Preparation of levofloxacin eyedrops METHODS:Levofloxacin eyedrops was prepared with benzalkonium as bacteriostat,NaCl as osmotic-pressure regulating agent and PVP as thickener The content was determined with HPLC and the stability was observed in the range of 60℃～90℃ with 5℃ as a gradient RESULTS:Both the within-day and between-day RSDs were less than 3% The expected period of validity would be 1 5 years Irritation test showed that this preparation was not irritant to rabbit's eyes The preparation met the criterion in Chinese Pharmacopeia CONCLUSION:The Levofloxacin eyedrops is stable in quality
