Preparation of Rufloxacin Hydrochloride Gel
- VernacularTitle:盐酸芦氟沙星凝胶剂的研制
- Author:
Fu LIU
;
Gongzhu WU
- Publication Type:Journal Article
- Keywords:
rufloxacin hydrochloride;
gel;
preparation;
quality control
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare rufloxacin hydrochloride gel and establish a quality control method of the gel METHODS:Carbopol940 was used as the gel base,the content of rufloxacin hydrochloride was determined with UV-spectrophotometry and the stability test was performed RESULTS:There was a good linearity of calibration curve of rufloxacin hydrochloride in range 2～10?g/ml,r=0 9 999,the average recovery was 99 53%,RSD was 0 38%(n=6) The gel was stable CONCLUSION:The design of the gel formulation is reasonable The gel can be prepared feasibly and is stable in quality,convenient in use
