Effects of human urotensin II on ischemia/reperfusion injury in isolated perfused rat hearts
- VernacularTitle:尾加压素预处理对大鼠心脏缺血再灌注损伤的影响
- Author:
Xiuhua LIU
;
Xudong WU
;
Lirong CAI
;
Fengying LIU
;
Chaoshu TANG
;
Jingy SU
- Publication Type:Journal Article
- Keywords:
Peptides;
Heart;
Ischemic preconditioning;
Reperfusion injury
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of human urotensin II (hUII) on ischemia/reperfusion (I/R) injury in isolated rat hearts. METHODS: In the ischemia/reperfusion (I/R) model of isolated perfused rat hearts,the effects of hUII pretreatment on cardiac function was monitored with cardiac function software of MFL Lab200. ATP,total calcium,and malondialdehyde (MDA) content in myocardium were detected. The coronary perfusion flow (CPF) and lactate dehydrogenase (LDH) activity in coronary effluent were measured during reperfusion. RESULTS: In the hUII pretreated group,the release of LDH from myocardium was lower [(78.3?18.1)U/L] than I/R group [(109.3?23.9) U/L,P
