Effects of Shenmai injection on acute myocardial ischemia/reperfusion injury in rats
- VernacularTitle:参麦注射液对大鼠急性心肌缺血再灌注损伤的影响
- Author:
Li LI
;
Qif HUANG
- Publication Type:Journal Article
- Keywords:
Shenmai injection;
Myocardial reperfusion injury;
Reactive oxygen species;
Calcium overload;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of Shenmai injection on the acute myocardial ischemia/ reperfusion injury in rats. METHODS: The left-anterior coronary artery was ligated for 10 minutes and then loosed for 15 minutes to establish the animal model of acute myocardial ischemia/reperfusion injury. During the process,electrocardiogram was traced continuously to observe the arrhythmia caused by reperfusion. The levels of SOD,MDA,Na +,K +-ATPase and Ca 2+ -ATPase in ventricular myocardium were measured. The mitochondria was observed through electron microscope. RESULTS: Shenmai injection decreased the incidence of arrhythmia caused by reperfusion and shortened its duration. Shenmai injection improved the activity of SOD,Na +,K +-ATPase and Ca 2+ -ATPase,decreased the content of MDA in myocardium and relieved the injury of mitochondria. CONCLUSION: Shenmai injection had a protective effect on acute myocardial ischemia/reperfusion injury in rats. The mechanism may be related to relieving the injury caused by oxygen free radical and calcium overload. [
