Levels of CGRP and ET-1 in plasma of pulmonary artery and thoracic aorta and in the extractives of lung and ventricular tissues of the chronic hypoxic rats
- VernacularTitle:缺氧大鼠出、入肺血、肺组织及心室肌降钙素基因相关肽和内皮素-1含量的变化
- Author:
Junying DU
;
Kaifeng TIAN
;
Dongmei GAO
;
Ying LIU
;
Lingyan GOU
;
Yahui FU
;
Chaosh TANG
- Publication Type:Journal Article
- Keywords:
Calcitonin gene-related peptide;
Endothelin-1;
Hypoxia;
Pulmonary hypertension
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM AND METHODS: To explore the effects calcitonin gene-related peptide (CGRP) and endothelin-1(ET-1) on the mechanisms of hypoxic pulmonary hypertension (HPH),the contents of CGRP and ET-1 in plasma of pulmonary artery and thoracic aorta and in extractives of lung and ventricular tissues of the chronic hypoxic rats were determined by radioimmunoassay. The changes of their hemodynamic indices and right heart hypertrophy index were monitored simultaneously. RESULTS: The level of pulmonary artery plasma CGRP was significantly higher than that of thoracic aorta plasma,but just the reverse was ET-1 or the ratio of ET-1 and CGRP in control rats( P
