Effect of Nao-re-qing oral liquid on cAMP content in hypothalamus and CSF,and AVP content in ventral septal area of endotoxin-induced febrile rabbits
- VernacularTitle:脑热清对内毒素性发热家兔下丘脑、脑脊液cAMP及腹中隔区AVP含量的影响
- Author:
Zhiqin LIU
;
Yufeng JIANG
;
Xiaoli YUE
;
Yongping FAN
;
Wenrong WANG
;
Liwei REN
;
Qifu HUANG
;
Yimin HU
- Publication Type:Journal Article
- Keywords:
Fever;
Endotoxins;
Cyclic AMP;
Argipressin;
Rabbits
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the mechanism of Nao-re-qing oral liquid (NRQ) decreasing endotoxin (ET)-induced fever in rabbits. METHODS: (1) The ET-induced fever model was established in rabbits. Febrile response of rabbits was observed. (2) The arginine vasopressin (AVP) content in the ventral septal area (VSA),and cAMP content in hypothalarmus (HP) and CSF were determined by radioimmunoassay.RESULTS: (1) In ET group,the maximal increment in body temperature (?T) [(1.80?0.16) ℃],6 h thermal respone index (TRI_6)(11.31?0.20),the cAMP content in the HP [(1.35?0.21)nmol/g],the cAMP content in CSF [(66.69?1.82) nmol/L] and AVP content in the VSA [(30.80?9.59)ng/g ] were significantly higher than those in NRQ+ET group[?T(0.82?0.08) ℃,TRI_6(5.73?0.09),HP: cAMP(0.70?0.50)nmol/g,CSF: cAMP(56.86?1.34),AVP:(11.91?3.47)ng/g]( P
