The Influence of Ascites in Severe Acute Pancreatitis (SAP) on the Viability and Function of Peritoneal Macrophages
- VernacularTitle:重症胰腺炎性腹水对腹腔巨噬细胞功能影响
- Author:
Tianmin YANG
;
Jiabang SUN
;
Fei LI
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Acute disease;
Macrophage;
Peritoneum;
Ascites;
Biologic characteristics
- From:
Journal of Chinese Physician
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of ascites in severe acute pancreatitis (SAP) on the function and viability of peritoneal macrophages in order to investigate the role of peritoneal macrophages in pathophysiological alteration and secondary pancreatic infection in SAP. Methods After the ascites of SAP models treated peritoneal macrophages for 1,3,6,12 and 24 hours in vitro, neutral red phagocytosis, cell viability and TNF secretion of peritoneal macrophages were determined respectively. Results The phagocytosis, cell viability and TNF secretion of macrophage all decreased with the treating time prolonged in the tests. Conclusions The ascites of SAP decreased the phagocytosis, viability and TNF secretion of peritoneal macrophages, and was one of the factors to promote secondary pancreatic and peripancreatic infection as well as bacterial translocation of gut.
