Expression of costimulatory molecules on peripheral blood lymphocytes in patients with Behet's disease
- VernacularTitle:Behcet病患者外周血淋巴细胞共刺激分子的表达
- Author:
Hong WANG
;
Peizeng YANG
;
Zhen ZHANG
- Publication Type:Journal Article
- Keywords:
Uveitis/etiology;
Uveitis/therapy;
Lymphocyte transformation;
Flow cytometry
- From:
Chinese Journal of Ocular Fundus Diseases
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of costimulatory molecules( B7, CD28, and CTLA-4) of peripheral blood lymphocytes in patients with Behcet′s ) disease(BD). Methods Lymphocytes were obtained in 24 patients with BD and 20 healthy individuals, and the expression of CD80(B7-1), CD86(B7-2), CD28 and CTLA-4 on T and B cells were detected by direct three-color immunofluorescence flow cytometry. Results Significantly increased expression of CTLA-4 on CD4 + T cells [(3. 18?1. 18)%] was found in BD patients compared with that in controls [(1. 73?0. 66) %] ( t=-3. 722,P
