Study on the Mechanism of UVB Irradiation and(-)-epigallocatechin-3-gallate Protection on Apoptosis of Cultured Human Keratinocytes
- VernacularTitle:紫外线诱导角质形成细胞凋亡和表没食子儿茶酚没食子酸酯保护机理的探讨
- Author:
Jiping XIA
;
Xiuzu SONG
;
Zhigang BI
- Publication Type:Journal Article
- Keywords:
Keratinocytes;
Ultraviolet rays;
Apoptosis;
(-)-epigallocatechin-3-gallate
- From:
Chinese Journal of Dermatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
0.25)levels in the two groups.In the group treated with42mJ/cm 2 UVB irradiation followed by the addition of EGCG,the numbers of apoptotic and dead cells and Fas mRNA were decreased,but bcl-2protein was increased.Conclusions Low dosage of UVB irradiation could induce apoptosis of keratinocytes.High dosage of UVB irradiation might result in cell death.EGCG could reduce UVB-induced apoptosis of keratinocytes by increasing bcl-2protein and decreasing Fas mRNA.
