Localization and expression of TGF-? _(1,2) in fetal and adult skins
- VernacularTitle:转化生长因子-?_(1,2)在不同发育阶段皮肤组织中的定位及表达量的变化
- Author:
Wei CHEN
;
Xiaobing FU
;
Tongzhu SUN
;
Zhili ZHAO
;
Gang ZHOU
;
Peng SUN
;
Yinhui YANG
;
Zhiyong SHENG
- Publication Type:Journal Article
- Keywords:
Transforming growth factor beta;
Alpha-smooth muscle acti n;
Fetal skin;
Scarless healing
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the localization and expression of transfo rming grow th factor-? 1,2 (TGF-? 1,2 ) and alpha-smooth muscle actin (?- ASMA) in fetal a nd adult skins. METHODS: Skins of 15 cases of fetuses with different gestational ages and 5 cases of adults were taken, embedded with paraffin wax, and sectione d. Immunohistochemistry method and pathological method were used to detect the e xpression intensity and distribution of TGF-? 1,2 and ?-ASMA. RESULTS: Positive immunohistochemical signals of TGF-? 1,2 and ?-A SMA were found in fetal and adult skins. In skins derived from young fet us, the positive signals of these three proteins were very weak. Along with the incr ement in gestational age, the positive cellular rates of TGF-? 1,2 and ?- ASMA were elevated pro gressively. In elder fetal and adult skins, TGF-? 1,2 were mostly distributed i n epidermal cells, endothelial cells and some fibroblasts, while ?-ASMA was mainly located in myofibroblasts and sweat gland epithelial cells. CONCLUSION: The endo genous TGF-? 1,2 might be involved in the cutaneous development at embryoni c stage, in the cutaneous structure maintenance at adult stage, and in the wound healing af ter injury.
