Effects of tumor necrosis factor alpha on proliferation and apoptosis of HSCs
- VernacularTitle:肿瘤坏死因子-?对肝星状细胞增殖与凋亡的影响
- Author:
Huiqing JIANG
;
Dongqiang ZHAO
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-alpha;
Hepatic stellate cells;
Proliferation;
Apoptosis
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the role of tumor n ecrosis factor alpha(TN F-?) in the pathogenesis of liver fibrosis. METHODS:The proliferation and apoptosis of hepatic stellate cells (HSCs) in vitro were detected with flow cytometry, electron microscopy and TUNEL. RESULTS:The flow cytometry analysis showed that the cell pr oliferation index (PI) in the TNF-?(0.5 ?g/L, 2.0 ?g/L, 8.0 ?g/L) groups was evidently l ower than that in the control group ( P
