The regulation of nitric-oxide synthase/nitric-oxide system by endogenous carbon monoxide in rats with pulmonary hypertension
- VernacularTitle:内源性CO对肺动脉高压大鼠NO体系的调节
- Author:
Xiaoying HUANG
;
Liangxing WANG
;
Shaoxian CHEN
;
Zhengjie XU
;
Xiaofang FAN
- Publication Type:Journal Article
- Keywords:
Carbon monoxide;
Heme oxygenase;
Nitric oxide;
Nitric oxi de synthase;
Anoxia;
Hypercapnia;
Hypertension,pulmonary
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the role and the mechani sm of heme oxygenas/endogenous carbon monoxide on nitric oxide synthase/nitric oxide system in rats with pulmo nary hypertension induced by hypoxic hypercapnia. METHODS: Spr ague-Dawley rats w ere randomly divided into three groups: control group (A group),hypoxic hypercap n ic group (B group), hypoxic hypercapnia+hemin group (C group). Blood CO concentr at ion (COHb%),NO concentration,HO-1 activity, iNOS, cNOS in blood serum and lung h omogenate were measured, respectively. RESULTS: ① mPAP and RV /(LV+S) of B g roup were significantly higher than those of A and C group( P
