Serum contents of E-selectin, sICAM-1,sVCAM-1 in patients with acute coronary syndrome
- VernacularTitle:急性冠脉综合征病人血清中E-选择素、可溶性细胞间粘附分子-1和可溶性血管细胞间粘附分子-1含量的变化
- Author:
Shaomin CHE
;
Yanni WANG
;
Aiqun MA
;
Lu GAO
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Inflammation;
Vascular cell ad hesion molecule-1
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the serum levels of certain adhesion mole cules and its significance in acute coronary syndrome(ACS). METHODS: The subjects included 40 patients with acute myocardial infarction(AMI) and 40 patients with unstable angina pectoris (UAP). Among the 80 patients, 60 patients accepted a follow- up 4 months. At the same time we selected 40 controls from people who atte nded a routine health check in the university. Serum levels of E-selectin,sICAM -1,sVCAM-1 were measured by ELISA. RESULTS: Serum level s of E-selectin ,sICAM-1,sVCAM-1 were significantly higher in the ACS group(AMI or UAP) than in the control group. Four months later, the levels of E-selectin,sICAM-1 bec ame sig nificantly lower in the follow-up group than in the ACS group, while sVCAM- 1 showed no significant difference. CONCLUSION: Serum levels of E-se lectin ,sICAM-1 may have certain diagnostic value for ACS, and can be a useful marker reflecting th e stability of the disease.
