Association among COX_2, iNOS and p38MAPK in late phase of preconditioning in rat cardiomyocytes
- VernacularTitle:大鼠心肌细胞缺氧预处理中COX_2、iNOS和p38MAPK间信号转导关系的研究
- Author:
Junyong HAN
;
Yunzhen CHEN
- Publication Type:Journal Article
- Keywords:
Ischemic preconditioning;
Prostaglandin-endo peroxide synthase;
p38 MAP kinase;
Nitric-oxide synthase;
Signal transduction
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). The LDH was lower ,and cell viability was higher in group IPC than those in control group. The LDH was higher ,and cell viability was lower in grou p SMT, group NS 398 and group SB than those in group IPC. CONCLUSIONS: In late p hase of preconditioning ,the p38MAPK activity and expression of iNOS and COX 2 increase significantly in rat cardiomyocytes, activited p38MAPK mediates iNOS ,then promotes COX 2 expression.
