Effects of ATP binding cassette transporter A1 on choles terol efflux in macrophages
- VernacularTitle:三磷酸腺苷结合盒转运体A1在巨噬细胞胆固醇流出中的作用
- Author:
Chaoke TANG
;
Pengke YAN
;
Yongzong YANG
- Publication Type:Journal Article
- Keywords:
ATP binding cassette transporter A1;
Cholesterol efflux;
Atherosclerosis
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Tangier disease is caused by mutations in ATP binding cassette transporter A1( ABCA1). ABCA1 interacts with lipid-free apolip oproteins, promoting phospholipid and cholesterol efflux from cells and giving r ise to HDL particles. ABCA1 may act as a phospholipid translocase facilitating p hospholipid binding to apoA-I. ABCA1 gene expression is upregulated in cholester ol-loaded cells as a result of activation of LXR/RXR-mediated gene transcription . LXR and RXR coordinately induce a battery of genes mediating cellular choleste rol efflux, centripetal cholesterol transport, and cholesterol excretion in bile . Small-molecule activators of LXR/RXR or other stimulators of macrophage or int estinal cholesterol efflux hold great promise as future treatments for atheroscl erosis.
