An experimental study on warm ischemia injury and cytokine expression in liver transplantation
- VernacularTitle:肝移植热缺血损伤与细胞因子表达的研究
- Author:
Jiqi YAN
;
Hongwei LI
;
Chenghong PENG
;
Mingjun ZHANG
;
Weiping YANG
;
Weiyao CAI
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Reperfusion injury;
CytokinesHJHK
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between donor liver warm ischemia and postoperative cytokine expression in liver transplantation from non-heart-beating donors.Methods Rat orthotopic liver transplantation was performed in three groups (HB, NHBD-30 and NHBD-60) according to the non-heart-beating time of 0, 30 or 60 minutes before donor liver was harvested. The serum values of TNF-?, IL-6 and CINC in each group after transplantation were determined.Results Over time of warm ischemia to which the donor liver was exposed, the concentrations of TNF-?, IL-6 and CINC elevated with significant difference among those three groups. TNF-?, IL-6 and CINC reached its peak value at 3 hours, 6 hours and 6 hours after transplantation respectively.ConclusionsKG1 In liver transplantation from non-heart-beating donors, the upregulation of TNF-?, IL-6 and CINC was associated with warm ischemia injury.
