Determination of the Serum Concentration of Buspirone by HPLC in Rabbits
- VernacularTitle:高效液相色谱法测定兔血清中丁螺环酮的浓度
- Author:
Weijuan ZHAO
;
Jiaming BIAN
;
Jingfeng XU
- Publication Type:Journal Article
- Keywords:
HPLC;
Buspirone;
serum drug concentration
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a HPLC method for determination of the concentration of Buspirone in serum.MET_ HODS:The chromatographic system consisted of ZORBA SB-C 18 column and mobile phase of methanol-acetonitrile-water-0.1mol/L NaAC buffer solution(pH4.5)(10∶38∶51∶1),with a detection wavelength of237nm,and the content was calcu?lated by peak area internal standard method.RESULTS:The linear range of Buspirone was1～80ng/ml,r=0.9979.CONCL_ USION:This method is simple and accurate for determination of Buspirone in serum.
