Effects of Shuanghuanglian on Pharmacokinetics of Theophylline in Healthy Subjects
- VernacularTitle:双黄连对氨茶碱药动学的影响
- Author:
Yunping JIANG
;
Renjie ZENG
;
Xiaolan YONG
;
Li JIANG
;
Rongmei LIANG
- Publication Type:Journal Article
- Keywords:
Shuanghuanglian;
theophylline;
pharmacokinetics;
HPLC
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of Shuanghuanglian on pharmacokinetics of theophylline in healthy sub?jects.METHODS:The serum concentration of theophylline was determined by HPLC and analyzed by3p97pharmacokinetic program.RESULTS:The main pharmacokinetic parameters of single theophylline and that in combined use with Shuanghuan?glian were as follows:T max were(1.66?0.56)and(1.59?0.78)h,C max were(6.23?1.31)and(6.10?0.94)?g/ml,T 1/2 were(5.76?1.11)and(6.09?1.63)h,CL were(47.72?5.12)and(50.98?10.85)ml/(kg?h),Vd were(369.18?40.15)and(430.37?48.33)ml/kg,AUC 0～∞ were(84.56?14.43)and(89.27?26.35)?g/(h?ml),respectively.CONCLUSION:The Vd of theophylline were increased(P
