Protective effect of liver ischemic preconditioning on the extrahepatic organs injury induced by liver ischemia/repurfusion in rats
- VernacularTitle:大鼠肝缺血预处理对肝缺血再灌注所致肝外脏器损伤的保护作用
- Author:
Yongqiang ZHAN
;
Xinsheng LU
;
Kai ZHENG
;
Chengyou WANG
;
Zhiming WANG
;
Xinying LI
;
Jinson HE
- Publication Type:Journal Article
- Keywords:
LIVER ISCHEMIA;
REPERFUSION INJURY;
DISEASE MODELS,ANIMAL;
SMALL INTESTINE/pathol;
KIDNEY/pathol;
ISCHEMIC PRECONDITIONING
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect of liver ischemic preconditioning on the extrahepatic organs injury induced by liver ischemia/repurfusion in rats. Methods Seventy-two Sprague-Dawley rats were randomly assigned into group IP,group I/R and group S (sham-operation group), each group had 24 rats. After ischemic preconditioning and ischemia/repurfusion animal models were set up,the pathological changes of small intestine, pancreas, myocardium, kidney, lung, brain and skeletal muscle tissues were observed at 2h,24h and 1week,respealively. Results (1) The degree(s) of small intestinal injury: at 2h and 24h, The injury in group IP and group I/R were significantly higher than that in group S (all P
