The Effect of Nitric Oxide on IL -1? and TNF-? in Liver Ischemic Precondition in Rats
- VernacularTitle:大鼠肝缺血预处理过程中一氧化氮对IL-1?及TNF-?的影响
- Author:
Xinsheng LU
;
Yongqiang ZHAN
;
Ziming WANG
- Publication Type:Journal Article
- Keywords:
Nitri oxide;
Liver;
Reperfusion injury;
IL-1?;
TNF-?
- From:
Journal of Chinese Physician
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of nitric oxide (NO) synthesis on serum interleukin 1? (IL-1?) and tumor necrosis factor ? (TNF-?) levels in liver ischemic preconditioning (IP) in rats. Methods 169 rats were randomly divided into ischemia/reperfusion (I/R) group, IP group,L-arginine plus IP (L-Arg+IP) group and sham operation group (S group). The concentrations of plasma NO, serum IL-1? and TNF-? were measured at 2h, 24h and 1 week after models were set up. Results ⑴ Plasma NO concentrations: In group IP and group L-Arg+IP,the NO concentration at all the 3 time points were significantly higher than those in group S (P0 05). Conclusions Liver ischemic preconditioning could down-regulate the levels of blood IL-1? and TNF-?, which may relate to the increase of NO synthesis. The increase of NO synthesis could enlarge this down-regulation effect, and further enhance the protective effect of IP on the liver I/R injury.
