The Expression of ERCC1, RRM1, and BRCA1 in Breast Cancer According to the Immunohistochemical Phenotypes.
10.3346/jkms.2011.26.3.352
- Author:
Dokyung KIM
1
;
Woohee JUNG
;
Ja Seung KOO
Author Information
1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. kjs1976@yuhs.ac
- Publication Type:Original Article
- Keywords:
Breast Neoplasms;
ERCC1;
RRM1;
BRCA1
- MeSH:
Adult;
BRCA1 Protein/*genetics/metabolism;
Breast Neoplasms/*genetics/metabolism/pathology;
DNA Repair;
DNA-Binding Proteins/*genetics/metabolism;
Disease-Free Survival;
Endonucleases/*genetics/metabolism;
Female;
Gene Expression;
Humans;
Immunohistochemistry;
Middle Aged;
Phenotype;
Prognosis;
Protein Array Analysis;
Receptor, Epidermal Growth Factor/genetics/metabolism;
Tumor Markers, Biological/*genetics/metabolism;
Tumor Suppressor Proteins/*genetics/metabolism
- From:Journal of Korean Medical Science
2011;26(3):352-359
- CountryRepublic of Korea
- Language:English
-
Abstract:
We studied the expression of BRCA1, ERCC1, and RRM1 which play an important role in DNA repair systems in breast cancer. Immunohistochemical staining for EGFR, BRCA1, ERCC1, and RRM1 were performed by using a tissue microarray made from 230 breast cancer patients. Patients were classified into luminal A, luminal B, HER-2, and triple negative breast cancer (TNBC) types according to ER, PR, and HER-2 expression. The expression of ERCC1, RRM1, and BRCA1 were correlated (P < 0.05). The expression level of ERCC1 was the lowest in TNBC type (P = 0.031), ERCC1 negativity was more prominent in TNBC and luminal B groups than luminal A and HER-2 groups (P = 0.013). Cases with EGFR overexpression showed high expression of RRM1 and BRCA1 (P = 0.046, and 0.004, respectively). In conclusion, the expression of ERCC1 is particularly lower in TNBCs than other types of breast cancers.
