Hypoxemia and Arrhythmia during Daily Activities and Six-minute Walk Test in Fibrotic Interstitial Lung Diseases.
10.3346/jkms.2011.26.3.372
- Author:
Jeong Hyun PARK
1
;
Yangjin JEGAL
;
Tae Sun SHIM
;
Chae Man LIM
;
Sang Do LEE
;
Younsuck KOH
;
Woo Sung KIM
;
Won Dong KIM
;
Roland Du BOIS
;
Kyung Hyun DO
;
Dong Soon KIM
Author Information
1. Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea. dskim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Arrhythmias, Cardiac;
Anoxia;
Lung Diseases, Interstitial;
Six-Minute Walk Test
- MeSH:
*Activities of Daily Living;
Aged;
Anoxia/*physiopathology;
Arrhythmias, Cardiac/*physiopathology;
Dyspnea/physiopathology;
Electrocardiography, Ambulatory;
Exercise Test;
Exercise Tolerance;
Female;
Humans;
Lung Diseases, Interstitial/*physiopathology;
Male;
Middle Aged;
Motor Activity/*physiology;
Oximetry;
Respiratory Function Tests;
Sleep;
Walking
- From:Journal of Korean Medical Science
2011;26(3):372-378
- CountryRepublic of Korea
- Language:English
-
Abstract:
We performed 24-hr monitoring of pulse oximetric saturation (SpO2) with ECG and six-minute walk test (6MWT) in 19 patients with fibrotic interstitial lung diseases (ILD) to investigate; 1) The frequency and severity of hypoxemia and dysrhythmia during daily activities and 6MWT, 2) safety of 6MWT, and 3) the parameters of 6MWT which can replace 24-hr continuous monitoring of SpO2 to predict hypoxemia during daily activities. All patients experienced waking hour hypoxemia, and eight of nineteen patients spent > 10% of waking hours in hypoxemic state. Most patients experienced frequent arrhythmia, mostly atrial premature contractions (APCs) and ventricular premature contractions (VPCs). There were significant correlation between the variables of 6MWT and hypoxemia during daily activities. All of the patients who desaturated below 80% before 300 meters spent more than 10% of waking hour in hypoxemia (P = 0.018). In contrast to waking hour hypoxemia, SpO2 did not drop significantly during sleep except in the patients whose daytime resting SpO2 was already low. In conclusion, patients with fibrotic ILD showed significant period of hypoxemia during daily activities and frequent VPCs and APCs. Six-minute walk test is a useful surrogate marker of waking hour hypoxemia and seems to be safe without continuous monitoring of SpO2.
