Predictors of Pulmonary Function Response to Treatment with Salmeterol/fluticasone in Patients with Chronic Obstructive Pulmonary Disease.
10.3346/jkms.2011.26.3.379
- Author:
Jae Seung LEE
1
;
Jin Won HUH
;
Eun Jin CHAE
;
Joon Beom SEO
;
Seung Won RA
;
Ji Hyun LEE
;
Eun Kyung KIM
;
Young Kyung LEE
;
Tae Hyung KIM
;
Woo Jin KIM
;
Jin Hwa LEE
;
Sang Min LEE
;
Sangyeub LEE
;
Seong Yong LIM
;
Tae Rim SHIN
;
Ho Il YOON
;
Seung Soo SHEEN
;
Yeon Mok OH
;
Sang Do LEE
Author Information
1. Department of Pulmonary and Critical Care Medicine, Asthma Center, and Clinical Research Center for Chronic Obstructive Airway Diseases, University of Ulsan College of Medicine, Seoul, Korea. sdlee@amc.seoul.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Pulmonary Disease, Chronic Obstructive;
Emphysema;
Corticosteroids;
Adrenergic beta-Agonists;
Respiratory Function Tests
- MeSH:
Aged;
Albuterol/*analogs & derivatives/therapeutic use;
Androstadienes/*therapeutic use;
Bronchodilator Agents/*therapeutic use;
Emphysema;
Female;
Humans;
Linear Models;
Lung/physiopathology;
Male;
Middle Aged;
Prognosis;
Pulmonary Disease, Chronic Obstructive/*drug therapy;
Republic of Korea;
Respiratory Function Tests;
Retrospective Studies;
Tomography Scanners, X-Ray Computed;
Treatment Outcome
- From:Journal of Korean Medical Science
2011;26(3):379-385
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and responses to therapies are highly variable. The aim of this study was to identify the predictors of pulmonary function response to 3 months of treatment with salmeterol/fluticasone in patients with COPD. A total of 127 patients with stable COPD from the Korean Obstructive Lung Disease (KOLD) Cohort, which were prospectively recruited from June 2005 to September 2009, were analyzed retrospectively. The prediction models for the FEV1, FVC and IC/TLC changes after 3 months of treatment with salmeterol/fluticasone were constructed by using multiple, stepwise, linear regression analysis. The prediction model for the FEV1 change after 3 months of treatment included wheezing history, pre-bronchodilator FEV1, post-bronchodilator FEV1 change and emphysema extent on CT (R = 0.578). The prediction models for the FVC change after 3 months of treatment included pre-bronchodilator FVC, post-bronchodilator FVC change (R = 0.533), and those of IC/ TLC change after 3 months of treatment did pre-bronchodilator IC/TLC and post-bronchodilator FEV1 change (R = 0.401). Wheezing history, pre-bronchodilator pulmonary function, bronchodilator responsiveness, and emphysema extent may be used for predicting the pulmonary function response to 3 months of treatment with salmeterol/fluticasone in patients with COPD.
