Expression of ET_(A-R) Gene in Cultured Normal Human Melanocytes
- VernacularTitle:体外培养正常人黑素细胞内皮素A受体mRNA表达的研究
- Author:
Juan DU
;
Qianxi XU
;
Peiying HE
;
Zheng YAN
;
Jianzhong ZHANG
;
Tiejun ZHU
- Publication Type:Journal Article
- Keywords:
Melanocytes;
Endothelin-1;
Receptors, endothelin
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of high selective A receptor of endothelin-1 (ETA-R) in melanocytes from normal human beings. Methods Normal human melanocytes were cultured and mR-NA expression of ETA-R in melanocytes was measured by reverse transcription-polymerase chain reaction. Results The mRNA expression of ETA-R was seen in melanocytes. Conclusion This study combined with other experiments suggests that endothelin-1 may affect melanocytes by high selective ETA-R which may con-tribute to the pathogenesis of vitiligo.
