A Decline in Renal Function is Associated With Loss of Bone Mass in Korean Postmenopausal Women With Mild Renal Dysfunction.
10.3346/jkms.2011.26.3.392
- Author:
Hack Lyoung KIM
1
;
In Young PARK
;
Jin Man CHOI
;
Se Min HWANG
;
Hyo Sang KIM
;
Jae Sung LIM
;
Min KIM
;
Min Jeong SON
Author Information
1. Armed Forces Seoul Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Association;
Bone Density;
Koreans;
Postmenopause;
Renal Insufficiency
- MeSH:
Absorptiometry, Photon;
Aged;
Blood Urea Nitrogen;
*Bone Density;
Creatinine/blood;
Female;
Femur Neck/physiology;
*Glomerular Filtration Rate;
Humans;
Kidney Diseases/*physiopathology;
Kidney Function Tests;
Lumbar Vertebrae/physiology;
Middle Aged;
Osteoporosis, Postmenopausal/*physiopathology;
Republic of Korea
- From:Journal of Korean Medical Science
2011;26(3):392-398
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was conducted to assess the relationship between estimated glomerular filtration rate (eGFR) and bone mineral density (BMD) in Korean postmenopausal women with mild renal dysfunction. A total of 328 postmenopausal women who underwent BMD measurement during health check-up was investigated. BMD was measured in lumbar spine (L1-L4), femoral neck, total proximal femur and femoral trochanteric areas by dual energy radiography absorptiometry and renal function was estimated by eGFR using Cockcroft-Gault equation. Of the 328 subjects, 317 (96.6%) had an eGFR > or =60 mL/min/1.73 m2. By using simple linear regression analysis, age, height, weight and eGFR were significantly associated with BMD for the 4 aforementioned anatomic sites, while serum levels of creatinine and blood urea nitrogen did not influence BMD. When multiple regression analyses were applied, age and body weight still had significant associations with BMD at 4 different anatomic sites (P < 0.001). A significant association of eGFR with BMD remained in the lumbar spine, femoral neck and proximal total femur (P < 0.05) but not in the trochanteric area (P = 0.300). Our study suggests that a decline of renal function is associated with lower BMD in the lumbar spine, femoral neck and total proximal femur areas in Korean menopausal women with mild renal dysfunction.
