Expression and role of CD134 and NF-?B in renal tissue of lupus nephritis
- VernacularTitle:狼疮性肾炎肾组织CD134共刺激信号对核因子-?B表达的影响
- Author:
Yanbin ZHOU
;
Rengao YE
;
Canmao XIE
;
Hanshi XU
;
Weiming GUAN
;
Xiao YANG
;
Nianshen YANG
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
NF-kappa B;
Immunohistochemistry
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of CD134 (OX40) and NF-?B in the pathogenesis of lupus nephritis (LN). METHODS: Renal in situ CD134 and NF-?B expression were examined in 40 biopsy specimens from LN patients by immunohistochemistry and microwave-based immunohistochemistry, respectively. The relationship between expression of CD134 and NF-?B was analyzed. RESULTS: The expression of glomerular and tubular CD134 and NF-?B in LN were higher than that in normal control, especially in class Ⅳ LN, where there was intense staining of endothelial cell, distal tubules, and interstitial mononuclear cell. The CD134 expression of glomerular and tubular was closely related to NF-?B expression, respectively ( r=0.5542,P
