Effect of puerarin on pulmonary arterioles wall collagen metabolism of chronic hypoxia hypercapnia rats
- VernacularTitle:葛根素对慢性低氧高二氧化碳大鼠肺动脉管壁胶原代谢的影响
- Author:
Yongsheng GONG
;
Jiwu LI
;
Penglin YANG
;
Xiaofang FAN
;
Lianggang HU
;
Lzhen ZHENG
;
Zhongsun JIANG
- Publication Type:Journal Article
- Keywords:
Puerarin;
Hypoxia, chronic;
Hypercapnia;
Hypertension,pulmonary;
Collagen
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effect of puerarin on pulmonary vessel collagen metabolism in pulmonary hypertension rats induced by chronic hypoxia and hypercapnia. METHODS: Collagen Ⅰ,Ⅲ and their mRNA were observed in pulmonary arterioles by the technique of immunohistochemistry and in situ hybridization. RESULTS: ① Light microscopy showed media thickness of pulmonary arterioles was much higher in HH(hypoxic-hypercapnia) group than that of NC(normal control) group, and, vessel cavity turned more straiter in HH group than that of NC group.However, the damage of pulmonary arterioles in HP(hypoxic-pueratin) group was much slighter than that of HH group. ② The levels of plasma ET-1 and lung homogenates Hyr were much higher in HH group than those of NC group( P 0.05). CONCLUSION: Puerarin inhibited the deposition of collagen and improved pulmonary vessel remodeling.
