Comparison of allodynic effect induced by intrathecal administration of nociceptin between two mouse strains
- VernacularTitle:鞘内注射孤啡肽对不同小鼠所致痛觉超敏的比较
- Author:
Meijin MENG
- Publication Type:Journal Article
- Keywords:
Endorphins;
Hyperalgesia;
Injections, spinal
- From:
Chinese Journal of Anesthesiology
1996;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the allodynic effect of intrathecal nociceptin between Swiss albino and C57 BL mice. Methods The allodynic effect was evaluated by allodynic scores by light touching using paintbrush. The allodynic effect of intrathecal nociceptin was observed over 50 min after injection in two mouse strains in a double blind manner. Results The allodynia induced by nociceptin lasted for 50 min in Swiss albino and no dose-response relationship was observed from dose 5 fmol- 50 pmol per mouse. In C57 BL mice, allodynic effect lasted for 30 min and showed a bell-shaped dose-response curve from dose 10 frnol-1 nmol per mouse. Conclusion These results demonstrate that the allodynic eflect of intrathecal nociceptin is different between strains.
