Effect of Salvia Miltiorrhiza, Ligustrazine and Magnesium Sulfate on Outcomes of Patients with Pregnancy-induced Hypertension
- VernacularTitle:丹参、川芎嗪、硫酸镁对妊娠高血压综合征患者母儿结局影响的比较
- Author:
Dunjin CHEN
;
Yang ZHAO
;
Ruojing SHE
- Publication Type:Journal Article
- Keywords:
Pregnancycomplications, cardiovascular;
Hypertension;
Salvia miltiorrhiza;
Magnesium sulfate;
Tetramethylpyrazine;
Endothelium;
Vascular;
Pregnancy outcome
- From:
Chinese Journal of Perinatal Medicine
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether therapy of Salvia miltiorrhiza,Ligustrazine and magnesium sulfate has effect on concentrations of SOD, MDA,NO,ET,TXA 2, PGI 2 in blood and outcomes of women with pregnancy-induced hypertension(PIH). Methods Two hundred and twenty-five women with moderate PIH were studied while treated with Salvia miltiorrhiza, Ligustrazine and magnesium sulfate in group A, B, and C(n=75 respectively). Concentrations of SOD, MDA, NO, ET, TXA 2, PGI 2 in blood, blood pressure, postpartum hemorrhage, fetal distress, and neonatal asphyxia were monitored. Results In maternal blood the concentrations of SOD in the three groups before and after treatment were 178.3?4.1 vs 219.5?4.1、190.4?2.4 vs 208.4? 2.4、176.1?3.4 vs 221.1?2.2、MDA 11.4?1.3 vs 7.2?1.2、13.0?2.7 vs 8.6?2.0、10.3?1.5 vs 7.1?1.1、NO 747?202 vs 940?232、798?159 vs 907?142、776?212 vs 862?189、ET 78.3?4.5 vs 62.3?3.8、78.3?4.3 vs 58.3?4.4、76.9?3.9 vs 60.2?2.9、TXA 2 560?28 vs 486?27、537?27 vs 502?20、558?25 vs 472?21、PGI 2 162?13 vs 217?14、167?17 vs 227?16、169?13 vs 213?11 respectively,there were significant differences between betore and after treatment (P0.05). Conclusions It is showed that Salvia miltiorrhiza ,Ligustrazine and magnesium sulfate can well balance circulating levels of SOD, MDA, NO, ET, TXA 2, and PGI 2 in women with PIH. Magnesium sulfate may interfere the results of the monitoring on the fetal heart rate.
