Expression of Neuroglobin Gene in Hypoxic-ischemic Brain Injury of Newborn Rat
- VernacularTitle:脑红蛋白基因在新生大鼠缺氧缺血性脑损伤脑中的表达
- Author:
Hangyan WANG
;
Meiyu DENG
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Globins;
Hypoxia-ischemia,brain;
Animals, newborn;
Rats;
Gene expression
- From:
Chinese Journal of Perinatal Medicine
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and change of neuroglobin (NGB) gene on hypoxic-ischemic brain injury. Methods Fourty-eight wistar rats of 7days old were divided into 6 groups randomly. Five study groups, study (1 min), study (5 min), study (15 min), study (30 min), study (60 min), and control group. The brain tissues were taken at 1 min, 5 min, 15 min, 30 min and 60 min after brain hypoxic-ischemia injury, and nucleic and immunohistochemistry method were used. One-way method of Stata soft-bage was used for statistics. Results There were time-depended pattern of the expression of NGB gene. It increased rapidly at 1 min after ischemia (A:1.236), there was significant difference from control group (A:0.641; P
