Mutation of ras gene and overexpresion of PCNA as prognostic parameters in gallbladder cancer
- VernacularTitle:ras基因和PCNA与胆囊癌预后的关系
- Author:
Lin ZHANG
;
Shengquan ZOU
- Publication Type:Journal Article
- Keywords:
GALLBLADDER NEOPLASMS/diag;
PROGNOSTIC;
GENE,RAS;
PCNA
- From:
Chinese Journal of General Surgery
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimative the relationship between ras gene mutation,PCNA overexpression and the recurrence and prognosis of gallbladder cancer.Methods PCNA was studied by ABC immunohistology, ras gene mutation by PCR-RELP analysis.Results Histology,Nevin staging and operative methods were relevant to the prognosis of gallbladder cancer.The patient with stag IV,V gallbladder cancer had a poor prognosis;radical operations could prolong patients survival time.The mortal risk of patients with ras gene mutation was 1.62 times higher than that without ras gene mutation,with high overexpression of PCNA was 2.2 times higher than that with low expression of PCNA. Conclusions Differentiation degree, Nevin′s staging, mutation of ras gene and overexpresion of PCNA could be the prognostic factors in gallbladder cancer,and could help to select the operative procedure and to eluvate the surrival.
