The role of lipid metabolic disorders of liver in calcium bilirubinate gallstone formation caused by partial biliary obstruction and infection in rabbits
- VernacularTitle:肝脂质代谢异常在兔胆道不全梗阻并感染致胆囊胆红素钙结石过程中的作用
- Author:
Lin FU
;
Lujia XIAO
- Publication Type:Journal Article
- Keywords:
CHOLESTASIS/metab;
LIVER/metab;
LIPID/metab;
CALCIUM BILIRUBINATE/metab;
CHOLELITHIASIS/etiol
- From:
Chinese Journal of General Surgery
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of lipid metabolic disorders of liver in the formation of calcium bilirubinate gallstone caused by biliary partial obstruction and infection in rabbits. Methods Forty-nine rabbits were divided randomly into 3 groups: the gallstone group A (n=15) and B (n=22), and the control group (group C, n=12). The calcium bilirubinate gallstone model was set up by using partial biliary obstruction and infection in rabbits. Following items were measured:(1)Concentration of plasma triglyceride (TG), phospholipids (PL), total cholesterol (TCh), free cholesterol (FCh), cholesterol with high desitity lipoprotein and its sub-components (HDL-Ch, HDL 2-Ch and HDL 3-Ch); (2)Concentration of bile glycocholic acid (GCA), glycodeoxycholic acid (GDCA) and FCh. Results (1) Compared with group C, the plasma PL increased sighificantly in both group A (P0.05). The plasma HDL-Ch in group B and HDL 2-Ch in group A and B were significantly lower than those in group C (P
