Establishment and Antibody Verification of the Animal Model of Sclerotic Skin Induced by Bleomycin
- VernacularTitle:博来霉素诱导硬皮病小鼠模型及其抗体测定的初步研究
- Author:
Lubing ZHU
;
Ming LI
- Publication Type:Journal Article
- Keywords:
Scleroderma,systemic;
Models,animal;
Bleomycin;
Antibodies,antinuclear
- From:
Chinese Journal of Dermatology
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish and verify the animal model of sclerotic skin induced by bleomycin(Blm).Methods To establish a mouse model for scleroderma in C3H/He mice by repeated local injection of100?L of Blm(200?g/mL)everyday for3weeks.Then,the specimens of skin,lung and serum were examined.Results After3week local Blm injections,an intense dermal sclerosis was shown in C3H/He mice.Compared with the control skin,increased dermal thickness and increased collagen histo-chemical index were found(P
