Treatment of Condyloma Acuminatum with Imiquimod Cream:A Randomized,Double-blind,Place-bo-controlled,Multi-central Clinical Trial
- VernacularTitle:咪喹莫特乳膏治疗尖锐湿疣随机、双盲、多中心研究
- Author:
Heng GU
;
Fanqin ZENG
;
Zaipei GUO
;
Zhenhui PENG
;
Zhigang BI
;
Xuejun ZHU
;
Kun CHEN
;
Qing GUO
;
Yizhi ZHANG
;
Huling YAN
;
Meihua ZHANG
;
Gangwen HAN
;
Baozhu CHANG
;
Xunquan LIU
;
Jiabi WANG
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
Administration,cutaneous;
Imiquimod
- From:
Chinese Journal of Dermatology
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of5%imiquimod cream in the top-ical treatment of condyloma acuminatum(CA).Methods A randomized,double-blind,parallel placebo-controlled clinical study was conducted.The test drug was topically used in CA patients,three times a week for8weeks.Patients whose warts cleared completely were followed up for one month to determine recurrence rates.Results Two hundred fifty-eight patients with anogenital warts were enrolled into this trial.One hun-dred twenty-nine patients were randomly selected to receive5%imiquimod cream;129patients were ran-domly chosen to receive placebo cream.Results showed that the cure rates were12.30%,32.79%,50%,60.66%respectively in study group for2,4,6,8weeks and were4.88%,14.63%,19.51%,26.02%respec-tively in control group for2,4,6,8weeks(P
