Expression of CXCR1and CXCR2mRNA in Peripheral Blood Polymorphonuclears in Patients with Psoriasis
- VernacularTitle:银屑病患者中性粒细胞中CXC型趋化因子受体CXCR1、CXCR2 mRNA的表达
- Author:
Guilan YANG
;
Zhiqiang CHEN
;
Jiarun ZHENG
;
Xinyu LI
;
Yun CHEN
;
Yumei LI
;
Jianming GAO
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Neutrophils;
Receptor,chemokine
- From:
Chinese Journal of Dermatology
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of chemokine receptors CXCR1and CXCR2in progressive plaque psoriasis and their clinical significance.Methods Reverse transcription-polymerase chain reaction(RT-PCR)technique was applied to semi-quantatatively analyze CXCR1and CXCR2mRNA expression in peripheral blood polymorphonuclears(PMNs)from30cases of psoriatic patients,14of the30patients which were treated until the70%of skin lesions resolved,and30healthy controls.The correlation between CXCR1/2and psoriatic area and severity index(PASI)was evaluated.Results CXCR1and CX-CR2mRNA levels in PMNs from psoriatic patients were1.30?1.18和1.62?0.97,respectively,which were markedly higher than those in normal controls(0.56?0.36,0.74?0.58,respectively)and treated patients(0.49?0.34,0.51?0.51,respectively.)(P
