Dynamic changes of the function and ultrastructure of gastric parietal cells under stress ulcer in rats
- VernacularTitle:应激性溃疡时大鼠胃壁细胞功能及超微结构的动态变化
- Author:
Yumei LI
;
Xiaoping ZOU
;
Zhaoshen LI
;
Guiyong PENG
;
Xianbao ZHAN
;
Zhenxing TU
;
Dianchun FANG
;
Guomin XU
- Publication Type:Journal Article
- Keywords:
Stress;
Gastric mucosa;
Parietal cell, gastric;
Ultrastructure;
Ulcer
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the dynamic changes of the function and ultrastructure of gastric parietal cells under stress and their relation with acute gastric mucosal lesions. METHODS: Thirty-two male SD rats were randomly divided into four groups, which were control group and 1,2,4 h groups under water restraint stress (WRS). The gastric fluid pH value and gastric mucosal ulcer index(UI) were measured. The ultrastructural changes of parietal cells were observed by transmission electronic microscopy (TEM). RESULTS: The study demonstrated that gastric acid secretion increased and gastric fluid pH value decreased gradually and significantly under WRS compared with control group( P
