Effect and mechanism of Qing-Kai-Ling on endotoxin-induced fever in rabbits
- VernacularTitle:清开灵对家兔内毒素性发热的作用及机制研究
- Author:
Yufeng JIANG
;
Danhui ZHANG
;
Qifu HUANG
;
Jing YAN
;
Xu JIA
;
Xuey LU
- Publication Type:Journal Article
- Keywords:
Endotoxins;
Fever;
Interleukin-1;
Cyclic AMP;
Argipressin
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the antipyretic mechanism of Qing Kai-Ling (QKL) injection on endotoxin (ET)-induced fever in rabbits. METHODS: Rabbit models of endotoxin (ET)-induced fever were duplicated. The rectal temperature was measured by digital thermograph. The cAMP and IL-1? content in the hypothalamus (HP), the cAMP content in the cerebrospinal fluid (CSF), and the arginine vasopressin (AVP) content in the ventral septal area (VSA) were determined by radioimmunoassay. RESULTS: ① QKL had significant antipyretic effect on ET-induced fever( P
